SRF and cardiac hypertrophy: Notably, expression of SRF increases during development and aging [23–25], and expression levels of various SRF target genes, such as atrial natriuretic factor, skeletal α- actin, cardiac α-actin, α-myosin heavy chain, and β-myosin heavy chain, change during processes like developmental maturation, cardiac hypertrophy, and cardiomyopathy [26, 27].