Notably, among double TET2 mutated cases, missense-missense, missense-truncating, and truncating-truncating combinations comprised only 6.5%, 37%, and 56.5% (3/46, 17/46, and 26/46) of all combinations, respectively (Fig. S6), as was previously described for myeloid neoplasms [34]. The gene discussed is TET2; the disease is myeloid neoplasm.