As a bifunctional protein, in addition to its role in redox balance, PRDX6 harbors both Ca2+-independent phospholipase A2 (iPLA2) and lysophosphatidylcholine acyltransferase (LPCAT) activities, which participate in tumor phospholipid remodeling to promote abnormal growth48. The gene discussed is PRDX6; the disease is neoplasm.