Clustering of IPD3, IPD4, IPD5 and IPD6 closer to LRRK2-PD and MIRO1-PD (Fig. 5c, d), and at the same time closer to healthy controls (Fig. 5f) suggests that they might share disease mechanisms with LRRK2-G2019S and MIRO1-R272Q associated PD. This evidence concerns the gene RHOT1 and Parkinson disease.