Although, in the LRRK2 dataset we did not find shared pathways between analysed core proteins and the top significant DEGs several isoforms of tubulins, such as TUBA1A, TUBB2B and TUBA1B were found in the list of top 100 significant DEGs, further suggesting that disrupted microtubule cytoskeleton organisation and altered axon guidance might be shared mechanisms between the four monogenic PD cases. This evidence concerns the gene TUBB2B and Parkinson disease.