Importantly, SIRT3 has delactylation activity [43], the removal of lactylation from the non-histone proteins on Cyclin E2 (CCNE2), a key cell cycle protein reported to be essential for cancer progression [44–46], is catalyzed by SIRT3 to suppress the proliferation, migration, and invasion of cancer cells [47]. The gene discussed is PROS1; the disease is cancer.