PRMT5 and neoplasm: For example, PRMT5 regulates the activation of protein kinase B (AKT) through direct methylation of arginine-15 (R15), and AKT signaling controls the expression of the epithelial–mesenchymal-transition (EMT) transcription factors ZEB1, SNAIL, and TWIST1, which coordinates the EMT procedures responsible for tumor metastasis [70].