Copper promotes angiogenesis by activating several pro-angiogenic factors, namely vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), tumor necrosis factor (TNF), and interleukin-1 (IL-1), thereby promoting tumor initiation, growth, and metastasis [53]. This evidence concerns the gene FGF2 and neoplasm.