Several of the identified loci have been implicated in ASCVD risk factors such as circulating lipids (LPA-PLG, APOE, TRIB1, KANK2), diabetes (CDKN2B-AS1, IGF2BP1) and obesity (LEPR, IGF2BP1). The gene discussed is PLG; the disease is obesity due to melanocortin 4 receptor deficiency.