To investigate the contribution of ADAMTS5 secreted by cancer cells, OVCAR3‐GFP cells were transfected with a non‐targeting siRNA control, Rab25 targeting, or ADAMTS5 targeting siRNAs (Fig. S3B) and the 3D invasion of co‐culture spheroids was measured (Fig. 10B). This evidence concerns the gene ADAMTS5 and cancer.