CETP and hypertriglyceridemia: Beyond these direct structural effects, alterations in HDL lipid composition may also significantly affect functionality through two primary pathways: First, CETP-mediated core lipid exchange: CETP facilitates the exchange of TG from TG-rich lipoproteins to HDL particles, particularly in the context of hypertriglyceridemia or postprandial TG elevation (9, 48).