POLE3 and premenstrual tension: In multivariable-adjusted models (Table 3), participants with PMS had lower TAC (β=−0.32, 95% CI −0.61 to −0.03; P=.03), lower MVPA (β=−.01, 95% CI −0.02 to −0.004; P=.004), lower M10 (β=−0.0006, 95% CI −0.001 to −0.0002; P=.003), and higher ASTP (β=5.68, 95% CI 1.86-9.50; P=.004) when compared to those with RRMS.