When compared to published rates of classified BRAF alterations identified on tissue-based testing,14 rates were higher for each cancer type assessed via ctDNA when comparable: 3.8% tissue-based CCA BRAF alteration rate compared to 5.3% on ctDNA, 1.12% tissue-based rate for GEA compared to 2.6% on ctDNA, and 1.49% tissue-based rate for PDAC compared to 1.49% for ctDNA. Here, BRAF is linked to cancer.