For example, AD is clinically characterized by an amnestic-predominant dementia and neuropathologically defined by the build-up of amyloid beta (Aβ) plaques and neurofibrillary tangles formed by hyperphosphorylated tau protein [3]; however, these lesions are frequently accompanied by cerebrovascular disease (CVD) [4] or Lewy body pathology [5], which can influence clinical presentation. Here, MAPT is linked to Alzheimer disease.