MNX1-rearranged samples had a gene expression signature similar to t(7;12)(q36;p13) pediatric AML (19, 59, 60), with, for example, an upregulation of AGR2, KRT72, and KRT73. Downregulated genes included several key cancer- and hematopoiesis-associated genes: HLX, TFEC, GFI1, GAPT, SPRY2, TLE4, ACVR1B, BIK, EVI2B, PIK3CG, INPPL1 (SHIP2), MYD88, MACC1, CSF3, and CD177. This evidence concerns the gene SPRY2 and cancer.