Suppression of key genes involved in hematologic malignancies, including HLX, TFEC, GFI1, EVI2B, TLE4, and MYD88, all shared with pediatric AML, suggest a transcriptional repressor activity for MNX1 in AML affecting cell proliferation and myeloid differentiation. This evidence concerns the gene GFI1 and acute myeloid leukemia.