Suppression of key genes involved in hematologic malignancies, including HLX, TFEC, GFI1, EVI2B, TLE4, and MYD88, all shared with pediatric AML, suggest a transcriptional repressor activity for MNX1 in AML affecting cell proliferation and myeloid differentiation. The gene discussed is TLE4; the disease is acute myeloid leukemia.