Both GSX2 and MNX1 are known to be activated by rare but recurrent translocations to the ETV6 locus: GSX2 by t(4;12)(q11-q12;p13) in adult AML (54) and MNX1 by t(7;12)(q36;p13) in pediatric AML (19). This evidence concerns the gene GSX2 and acute myeloid leukemia.