Samples with MNX1 rearrangements had a unique mutational spectrum with an absence of NPM1 and FLT3 mutations (0/19), as well as a very high frequency of BCOR mutations (10/19), which are usually rare in AML (2/200 in TCGA-LAML), although they have recently been reported to have a frequency of about 10% in AML with del(7q) (Fig. 5C; Supplementary Table S15; ref. 11). This evidence concerns the gene FLT3 and acute myeloid leukemia.