Although no samples from the TCGA-LAML, BEAT-AML, and TARGET-AML cohorts expressed EPO, we found that among three AEL cohorts profiled with RNA-seq (47–49), one sample from each cohort expressed EPO (Fig. 3B), indicating that EPO expression is a rare but recurrent event in AEL. This evidence concerns the gene EPO and acute myeloid leukemia.