Interestingly, a single ClinVar submitter reported a human proband with hearing impairment and a SEMA3F missense variant of uncertain significance and unspecified zygosity localizing to the same Ig-like domain as the variant harbored by proband ENG_CMK (c.1849G>A, p.(Val617Met), Variation ID: 1064910; Supplementary Fig. S4A), supporting putative association between SEMA3F variants and hearing impairment.38 Here, SEMA3F is linked to Hearing impairment.