Notably, human heterozygous SEMA3F missense variants of uncertain significance localizing to diverse SEMA3F protein domains were previously described in individuals with hypogonadotropic hypogonadism with or without anosmia who were not reported to have CFEOM, hearing impairment, or other syndromic features in proband ENG_CMK (Supplementary Fig. S4A).39 This evidence concerns the gene SEMA3F and Kallmann syndrome.