L4 and, to a lesser extent, L3 induced a significantly higher secretion of IL-1β on day 1 post-infection (median scaled responses 1.54 [L4] and 1.31 [L3] vs. 0.55 [L1], 0.94 [L2], and 0.89 [L5]) (Figure 6C, left). The gene discussed is IL1B; the disease is infection.