CD8A and neoplasm: While abnormal levels of certain hormones have been linked to PDAC progression, the impact of PPY on the tumor microenvironment was previously unknown.[32, 33, 34] In this article, we demonstrated that PPY‐induced iCAFs promote macrophage polarization to an immunosuppressive M2 phenotype and recruit MDSCs, ultimately leading to CD8+ T cell exhaustion and an immunosuppressive environment.