PLCG2 and familial pancreatic carcinoma: However, recent research has also implicated EGFR in myCAF function and pancreatic cancer metastasis.[30] They found that EGFR/ERBB2 signaling was induced by TGF‐β in myCAFs through an autocrine process mediated by amphiregulin, and the phosphorylation of Y1068 was important during the process.[30] While Y1068 phosphorylation primarily recruits GRB2 to activate MAPK signaling,[42] our analyses showed that PPY treatment downregulated GRB2 expression while upregulating PLCG2 expression (Figure 6B–F).