Human CAFs and murine CAFs were respectively isolated from pancreatic cancer tissues from PDAC patients and KPC (KrasLSL‐G12D/+; Trp53LSL‐R172H/+; Pdx1‐Cre) mice, and the purity of these CAFs was assessed based on their morphology and immunohistochemical staining for FAP (labeled in red) and α‐SMA (labeled in green) prior to subsequent experiments (Figure S3B,C, Supporting Information). Here, FAP is linked to pancreatic neoplasm.