Despite extensive lung pathology data from deceased COVID-19 patients (109, –, 111), due to the lack of autopsy and lung biopsy samples from TLR7- and IFN-deficient patients, the distribution of pulmonary lesions and SARS-CoV-2 antigens in the lungs of TLR7- and IFN-mutant/deficient COVID-19 patients is not known. Here, IFNA1 is linked to COVID-19.