While increased SARS-CoV-2 N antigen levels in lung epithelial cells are likely due to reduced IFN/ISG response, the same might not be true for increased N antigen in lung macrophages, as these cells are not permissive to SARS-CoV-2 infection (38, 112), and if infected, it is a non-productive infection. The gene discussed is IFNA1; the disease is infection.