Indeed, previous studies report that glutamine anabolism is increased in GBM compared to the normal brain.[10, 11] Here, our results show that GBM cells rewire the metabolic flux toward de novo nucleotide biosynthesis to promote cancer progression by HDAC6‐ and USP9X‐mediated GS stabilization (Figure 8J). The gene discussed is USP9X; the disease is glioblastoma.