For instance, one study reported a significant reduction in BDNF levels among clinical migraine patients.[47] Another study indicated that injecting BDNF into the ventrolateral PAG can protect the structure and function of the PAG, providing both anti‐epileptic and analgesic effects.[48] Current research identifies BDNF as a target in the pathophysiology and treatment of migraines. Here, BDNF is linked to migraine disorder.