Consistent with our findings with disulfiram, we observed a significant decrease in IL-1 and IL-18 release in GSDMD-/- THP-1 macrophages (Okondo et al., 2017; Taabazuing et al., 2017) compared to WT THP-1 macrophages following Salmonella infection (Figure 3A; Figure 3—figure supplement 2A–B). This evidence concerns the gene IL1A and Salmonella Infections.