Human macrophages undergo NAIP/NLRC4- and NLRP3-dependent inflammasome activation during Salmonella infection (Bierschenk et al., 2019; Gram et al., 2021; Naseer et al., 2022a), which restricts intracellular Salmonella replication (Naseer et al., 2022a). Here, NLRC4 is linked to Salmonella Infections.