C3 and escherichia coli infection: Notably, the differentially expressed genes (DEGs) and functional enrichment revealed that C11 (e.g., CXCL14, TWIST2, TSPAN8 and APOD) harbouring the activation of cytokine‐cytokine receptor interaction and chemokine signalling pathway, and C3 (e.g., FN1, FXYD5 and GPC6) harbouring the activation of pathogenic Escherichia coli infection and ECM receptor interaction (Figure S1N).