For example, CAFs can over‐secret ANXA2, which triggers EMT in lung cancer cells; this pro‐EMT phenotype is dependent on the secretion of hepatocyte growth factor (HGF) and insulin‐like growth factor 1 (IGF1) by CAFs, thus facilitating the cancer cells' evasion of EGFR targeting.54 This evidence concerns the gene ANXA2 and cancer.