IL6 and narcolepsy: Notably, acute sleep deprivation andday-to-day reductions in sleep of 25-50% have shown increased levels of interleukin-6 (IL-6) and C-reactive protein (CRP)[8, 9-10].Individuals with primary insomnia have been shown to exhibit elevated IL-6 levels and PGE2 [11].Additionally, increased levels of brain PGD synthase, responsible for synthesizing PGD2, have been observed to be associated withincreased daytime sleepiness in patients with narcolepsy [12].