A study by Mantua et al. on young adults found a linearincrease in CRP with napping and they suggested interactive effects of excess/insufficient sleep and frequent/infrequent napping withelevated CRP but concluded that these relations depend on both nocturnal and daytime sleep patterns [39].Thus, a significant positive association of sleep disturbance and daytime disturbance with CRP in present study may be the probablecausative culprit for changed pain threshold in chronic pain like FMS (Figure 1 - see PDF). The gene discussed is CRP; the disease is chronic cystitis.