CXCL8 and cancer: Interleukin-8 (IL-8) initially recognized as a neutrophil chemoattractant and a key mediator of leukocyte-driven inflammation, plays a critical role in cancer progression in various cancers includingOC [40, 41-42].Elevated IL-8 levels in serum, ascetic fluid and tumor tissues, along with its overexpression, are strongly associated with poorprognosis and decreased survival in OC patients [43].