For CA125, the AUC was 0.81 (p < 0.001) in premenopausal and 0.671 (p = 0.002) in postmenopausal groups.Cut-off concentrations to predict lymph node metastasis: Premenopausal - HE4 = 52.95 pmol/l, CA125 = 69.45 U/ml; Postmenopausal -HE4 = 69.15pmol/l, CA125 = 21.45 U/ml. The gene discussed is MUC16; the disease is metastatic malignant neoplasm in the lymph nodes.