Our specific inclusion criteria were as follows: (1) pathological confirmation of endometrial cancer; (2) CTscan was performed before the operations; (3) preoperative detection of serum CA125 and HE4; (4) planned extra fascial hysterectomy,sub-extensive hysterectomy or extensive hysterectomy, double appendectomy, or pelvic with/without para-aortic lymph node dissection, toobtain complete postoperative pathological data. The gene discussed is WFDC2; the disease is endometrial cancer.