Yildizet al. have reported a cut-off value for diagnosis of lymph node metastasis using serum CA125 of 20 U/mL [17].Dobrzycka has reported an HE4 cut-off value of 78pmol/L for evaluating lymph node metastasis of endometrial cancer [18].Therefore, the standard values of serum CA125 and HE4 in the evaluation of endometrial cancer are worth discussing. The gene discussed is MUC16; the disease is endometrial cancer.