WFDC2 and metastatic malignant neoplasm in the lymph nodes: Moreover, the authors found that age and menopause status are important factors [10].Although researchers at the 2016 ESMO-ESGO-ESTRO meeting have proposed that HE4 is associated with lymph node metastasis, muscularinvasion, staging and differentiation of endometrial cancer, no consensus has been reached regarding the appropriate cut-off value forHE4 [11].