A GWAS-based on changes in prediabetes status has identified five novel genes associated with changes in prediabetes status, including SGCZ at 8p22, HPSE2 at 10q24.2, ADGRA1 at 10q26.3, GLB1L3 at 11q25, and PCSK6 at 15q26.3 (131). Here, PCSK6 is linked to prediabetes syndrome.