In a study by Qin Yang et al, sarcopenia was found to be an independent risk factor for all-cause mortality in patients with DFU, and therefore an important prognostic factor for patients with DFU (25), and sarcopenia is one of the poor prognostic factors for CKD (26).In the study of mortality outcomes in patients with DFU, cystatin C is a potential predictive marker in patients with DFU with a composite chronic kidney disease condition or independently reflecting an individual’s adverse muscular condition. This evidence concerns the gene CST3 and sarcopenia.