TG and early-onset autosomal dominant Alzheimer disease: In contrast, the top ten significantly downregulated pathways encompassed the thyroid hormone signaling pathway, ubiquitin system, diabetic cardiomyopathy, Parkinson’s disease, insulin resistance, Alzheimer’s disease, pathways of neurodegeneration (multiple diseases), chemical carcinogenesis (reactive oxygen species), and protein phosphatases and associated proteins (Figure 2E).