Investigations at age 15 years confirmed central hypothyroidism, FT4 7.3 pmol/L (8.4-19.1 pmol/L) [0.57 ng/dL (0.65-1.48 ng/dL)], TSH 1.53 mIU/L (0.3-5.0 mIU/L), LH 0.7 IU/L, FSH 4.1 IU/L, testosterone 7.6 nmol/L [219 ng/dL), IGF-1 11.2 ng/mL (13.5-66 ng/mL) [1.47 nmol/L (1.77-8.65 nmol/L)], prolactin 136 IU/L (90-300 IU/L) [6.39 μg/L (4.23-14.1 μg/L)], antimüllerian hormone 28.1 pmol/L (5.5-103 pmol/L). This evidence concerns the gene IGF1 and Central hypothyroidism.