The highest CrF after averaging across eight genetic ancestries was for BTD (AR; biotinidase deficiency; 1/17; 382 million), followed by HFE (AR; hemochromatosis; 1/28; 471 million) and ATP7B (AR; Wilson disease; 1/54; 137 million) (Additional File 1: Tables S3, S8 and S11). This evidence concerns the gene ATP7B and biotinidase deficiency.