The highest GP was observed for TTN (AD; dilated cardiomyopathy; 1/76; 117 million), TTR (AD; familial transthyretin amyloidosis; 1/89; 51 million), and LDLR (AD; familial hypercholesterolemia; 1/196; 46 million) across eight genetic ancestries. This evidence concerns the gene LDLR and familial amyloid neuropathy.