Among these, 10 SOCs (SOC 4 (Immune system disorders), SOC 6 (Metabolism and nutrition disorders), SOC 11 (Cardiac disorders), SOC 12 (Vascular disorders), SOC 13 (Respiratory, thoracic and mediastinal disorders), SOC 16 (Skin and subcutaneous tissue disorders), SOC 17 (Musculoskeletal and connective tissue disorders), SOC 22 (General disorders and administration site conditions), SOC 25 (Surgical and medical procedures), SOC 27 (Product issues)) demonstrated statistically significant associations with vaccine manufacturers. This evidence concerns the gene SOCS4 and subcutaneous tissue disorder.