AKAP11 and major depressive disorder: Strikingly, given the finding of genetic risk of AKAP11 variants in SCZ and BD, the enrichment analysis of the DAPPSs corresponding proteins through the DisGeNET38 database reveals an enrichment of diseases such as SCZ, BD, intellectual disability, neurodevelopmental disorders, and unipolar depression in Akap11-cKO brains (Fig. 3b).