As an RNA-binding protein, IGF2BP3 critically controls tumor invasiveness and metastasis by regulating the stability and translation of multiple oncogenic transcripts, such as HMGA2 (Jeng et al, 2008; Sheen et al, 2015), E2F3 (Wang et al, 2022), and EGFR (Chen et al, 2023). This evidence concerns the gene IGF2BP3 and neoplasm.