These analyses consistently demonstrated elevated IGF2BP3 levels in metastases versus primary tumors within the TCGA pan-cancer cohorts and the TCGA skin cancer dataset (Supplementary Figure S3a) and in skin, colon, liver, and kidney cancers from the TNMplot (Supplementary Figure S3b), highlighting its crucial role in tumor metastasis across multiple tumor types. This evidence concerns the gene IGF2BP3 and skin cancer.