Microorganisms in the placenta can promote the release of anti-angiogenic factors like soluble fms-like tyrosine kinase-1 (sFlt-1) while reducing the release of pro-angiogenic factors such as placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), affecting the vascularization status and causing endothelial dysfunction, ultimately leading to the clinical manifestations of Preeclampsia (Villar et al., 2006; Olaniyi et al., 2020). The gene discussed is PGF; the disease is endothelial dysfunction.