HIF1A and neoplasm: In this study, we report a photosensitive iridium complex MitoIrL2, which enabled the simultaneous mitochondrial modulationof macrophages and tumor cells to achieve synergistic antitumor immunity.The adjustment of the mitochondrial respiratory chain, HIF-1α,and the NF-κB pathway in macrophages drove the metabolic reprogrammingfrom oxidative phosphorylation (OXPHOS) to glycolysis, convertingprotumor M2 into the antitumor M1 phenotype.