TP53 and neoplasm: Furthermore, we found that tumors with the ID2 signature were associated with poor survival (HR=1.8, P=0.0021) and the occurrence of metastases (Fisher's exact test: OR=2.5, P=5.58e-03; Logistic regression: P=0.039 after adjust tumor purity, age, sex and TP53 mutation status) (Fig. 3c–d; Supplementary Fig. 23e-h).