We found that ZNF695, a transcription factor upregulated in ID2-positive tumors, and located on chr.1q, a typically amplified region in lung cancers, was enriched with non-canonical transcripts lacking the DNA-binding zinc-finger domain and unable to recruit DNA methyltransferases, likely resulting in decreased methylation levels at the L1 locations due to a dominant negative effect. This evidence concerns the gene ID2 and lung carcinoma.