Within this cluster, M4, the Ubiquitination module, showed strong correlations with CSF Aβ, total tau, and pTau181, as well as APOE genetic risk (quantified by number of the APOE2, APOE3 and APOE4 alleles, scaled by risk) and cognitive impairment (assessed via MoCA score). This evidence concerns the gene MAPT and Cognitive impairment.