In line with this, the synaptic-enriched M5 (Glycolysis) module, which is strongly correlated with disease pathology and includes tau (MAPT) as a hub protein, was also low in Subtype 3 compared to other AD-like subtypes, suggesting that the lower immunoassay tau levels may be associated with the overall reduction of neuronal proteins in this module. The gene discussed is MAPT; the disease is Alzheimer disease.