M5, the Glycolysis module, was primarily composed of neuronally associated hallmarks of AD, such as tau (MAPT), NRGN, GAP43, CALM1, CAMK2A, and SYN1, but also included other AD proteins such as the plaque associated proteins SMOC1 and SPON136, 37. The gene discussed is SMOC1; the disease is Alzheimer disease.