Interestingly, NUDCD3 is enriched in the nervous system (Fagerberg et al., 2014) and has been reported to interact with KLHL proteins that are highly expressed in the brain, involved in actin-binding and neuronal development (rather than participating in the UPS), and implicated in neurological conditions and brain tumors (Dhanoa et al., 2013; Shi et al., 2019). The gene discussed is NUDCD3; the disease is brain neoplasm.