While low CD30 positivity, high Ki67 expression, and presence of large cells have been associated with poorer prognosis in lymphomas, currently there is limited evidence supporting a strong relationship between immunophenotypic profile and prognosis in PR.6, 7, 8, 9, 10 Thus, we reviewed the literature to identify clinical and histopathologic risk factors for multiple episodes of relapse, finding only one other case of multiple relapses with radiation monotherapy. Here, TNFRSF8 is linked to lymphoma.