Interestingly, mounting evidence has suggested that the suppression of Akt activated FoxO via nuclear translocation in breast cancer (Hill et al. 2014; Scodelaro Bilbao and Boland 2013), gastric cancer (Du et al. 2022; Lin et al. 2019) and lung cancer (Liu et al. 2012; Maekawa et al. 2009; Yu et al. 2017). Here, AKT1 is linked to lung cancer.