However, as PPARγ is reported to positively regulate the polarization of the M2 macrophages (Gionfriddo et al. 2020), downregulation of this protein may inhibit the polarization of the M2 macrophages, which may inhibit the progression of cancer in vivo (Na et al. 2013; Siveen and Kuttan 2009; Zhao, Zhang, et al. 2014b). The gene discussed is PPARG; the disease is cancer.