Five components of ZGCD, including lysine, quercetin, gamma- aminobutyric acid, stigmasterol, and beta-sitosterol, may play anti-DCM roles via the targets of ASS1, SERPINE1, CACNA2D1, AVP, APOB, ICAM1, EGFR, TNNC1, F2, F10, IGF1, TNNI2, CAV1, INSR and INS. Here, ICAM1 is linked to familial dilated cardiomyopathy.