In univariate logistic regression, among ER-negative patients, 93% had PR < 1% (P <0.001),71% had zero HER2 status (P <0.001),64.3% had invasive ductal carcinoma (P <0.001) and 78% had Ki67 > 14% (P <0.001). This evidence concerns the gene ESR1 and invasive ductal breast carcinoma.