Given that the homologous miR-193b-5p has been demonstrated to enhance cisplatin sensitivity in HCC cells by targeting the 3’-UTR of Mcl-1 (58), it is hypothesized that miR-193a-5p may similarly influence Mcl-1 protein stability through analogous epigenetic regulatory patterns, thereby attenuating chemotherapy-induced mitochondria-dependent apoptotic effects. This evidence concerns the gene MCL1 and hepatocellular carcinoma.