MiR-193a-5p can induce cisplatin resistance by inhibiting AP-2α expression in bladder cancer cells and reduce cisplatin resistance in lung cancer by targeting circ_0048856 (56, 57).miR-193a-5p mediates the development of chemoresistance in tumor cells by post-transcriptionally regulating apoptosis-related genes and signaling pathways, thereby significantly modulating the expression levels of anti-apoptotic proteins such as Mcl-1 and Survivin. This evidence concerns the gene MCL1 and lung cancer.