PIK3R3 was identified as a target gene of miR-193a-5p in colorectal cancer cells, mediating the effects of miR-193a-5p and circRNA_0000392, and enhancing AKT signaling, the miR-193a-5p inhibitor can alleviate the reduction in PIK3R3 expression caused by circRNA_0000392 siRNA. Here, AKT1 is linked to colorectal cancer.