It was discovered that OSMR knockdown suppressed the activation of JAK and STAT3 as well as the expression of CCL-2, implying that OSMR silencing could inhibit the stimulation of the JAK/STAT3/CCL-2 signaling pathway in tumor cells, potentially inhibiting the malignant behaviors of glioblastoma cells by regulating this pathway. This evidence concerns the gene STAT3 and glioblastoma.