MTOR and cancer: Wang et al. (2017) have identified A-to-I RNA editing hotspots in the miR-99a-5p mature sequence among 20 cancer types. In contrast, Tregs exhibit C-to-U RNA editing in the miR-100 seed region, which alters the miR-100 target from mTOR to SMAD2, further affecting Treg differentiation and formation (Negi et al., 2015).