The fusion gene NRIP1-MIR99AHG, detected in acute myeloid leukemia (AML), results in the overexpression of miR-99a transcription and disruption of the tricistronic miR-99a/let-7c/miR-125b-2 cluster, facilitating the production of T-cell progenitors and accelerating leukemia progression (Kerbs et al., 2022). The gene discussed is NRIP1; the disease is acute myeloid leukemia.