In ESCC, METTL14 mediates TRIB2 mRNA degradation via miR-99a-5p, whereas TRIB2 induces ubiquitin-mediated proteasomal degradation of METTL14 in a COP1-dependent manner (Liu et al., 2021b) (Fig. 1). The gene discussed is TRIB2; the disease is esophageal squamous cell carcinoma.