Yang et al. (2015, 2017) demonstrated the oncogenic effects of miR-100-5p. They targeted HS3ST2 to inhibit the Notch signaling pathway and apoptosis, attenuating cisplatin sensitivity. Upregulation of miR-100-5p is associated with primary tumorigenesis and progression of GC; miR-100-5p targets RNF144B, an E3 ubiquitin ligase. RNF144B interacts with pirh2, another p53 E3 ubiquitin ligase, to accelerate ubiquitin-mediated p53 degradation (Yang et al., 2017, 2015). This finding suggests that miR-100-5p is associated with genomic instability (Xu et al., 2023). This evidence concerns the gene TP53 and gastric cancer.