Univariate logistic regression analysis showed that age, sex, alcohol, history of non-alcoholic fatty liver or cirrhosis, history of diabetes, history of viral hepatitis, single lesion, ALT, ALB, total bilirubin (TB), LYMPH%, MONO%, NEUT%, MCV, MCH, RDW-SD, PLT, and LMR were identified as candidate predictors of malignant AFP-negative liver space-occupying lesions. This evidence concerns the gene ALB and non-alcoholic fatty liver.