Genetically predicted lower APOC3 and PCSK9 levels were similarly associated with reduced CAD risk (OR = 0.83, 95% CI = 0.75–0.92, P = 4.6e-04 and 0.76, 95% CI = 0.73–0.80, P = 1.6e-31, respectively). This evidence concerns the gene APOC3 and coronary artery disorder.