APOB and atherosclerosis: In vivo experiments support that APOC3 knockout may prevent atherosclerosis potentially by increasing the clearance of triglyceride-rich lipoproteins and their remnants.9,10 This is achieved through the activation of lipoprotein lipase11 and increased hepatic clearance of apolipoprotein B (APOB) containing lipoprotein particles.12 In humans, APOC3 interference by the small interfering RNA plozasiran led to a 62% decrease in triglyceride levels, a 46% decrease in remnant cholesterol, a 15% lower ApoB, and an 11% lower LDL-cholesterol.13