Zeini Zadeh et al. (2023) demonstrated that after 12 weeks of intensive exercise, RIPK1 expression in AD model rats was reduced to 1.44 times, MLKL to 1.66 times, and TNFR1 from 2.81 to 1.64 times. These findings suggest that exercise can suppress RIPK1 activation by modulating the TNF-α/TNFR1 pathway, thereby reducing necroptosis. Here, MLKL is linked to Alzheimer disease.