TNFRSF1A and Alzheimer disease: TNF/TNFR1-mediated necroptosis pathway is significantly upregulated in AD hippocampal neurons, as shown by increased pRIPK3 and pMLKL levels. This upregulation correlates with increased neuron loss and is more pronounced in female AD brains. Pharmacological inhibition of necroptosis reduces TNF-induced neuronal death.