Human neurons in AD mouse models show upregulation of MEG3, a long noncoding RNA that induces necroptosis. MEG3 overexpression in human neurons leads to necroptosis through activation of RIPK1/RIPK3/MLKL pathway. Pharmacological or genetic inhibition of necroptosis rescues neuronal loss. The gene discussed is MLKL; the disease is Alzheimer disease.