MAPT and Alzheimer disease: Hallmark pathological features of AD include extracellular amyloid-β (Aβ) deposits, intracellular neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein, neuronal and synaptic loss, neurovascular modifications, and reactive gliosis (Scheltens et al., 2021; Askenazi et al., 2023).