MAPT and Alzheimer disease: Emerging research suggests that exercise may mitigate AD through several mechanisms, including enhancing cerebral blood flow (Kaufman et al., 2021), improving mitochondrial function (Zhao et al., 2021), increasing neurotrophic factor levels (Wang X. et al., 2020), reducing oxidative stress (Wang W. et al., 2020), attenuating tau hyperphosphorylation (Wang et al., 2023a), and suppressing neuroinflammation (Quan et al., 2020).