While current studies indicate that exercise can modulate O-GlcNAc glycosylation and indirectly influence Tau protein phosphorylation, thereby safeguarding neurons from necroptosis, there is a paucity of research directly demonstrating that exercise mitigates necroptosis in AD by regulating the activity of OGT and OGA in the brain. The gene discussed is MAPT; the disease is Alzheimer disease.