MAPT and concussion: These changes may be related, but not limited to, mTBI-induced permeability of the BBB32 and neuroinflammation,33 both of which are known to be involved in iron accumulation.9,30 Iron has also been implicated in the hyperphosphorylation of tau proteins (p-tau)28 observed in mTBI-related tauopathies; its co-localization with p-tau thus identifies it as a promising early indicator of neurodegeneration.34,35