Moreover, the detection of N-terminal truncated C-terminal fragments derived from TDP-43 pathological cleavage in human post-mortem brain tissues has facilitated the discrimination of patients with ALS from patients with other neurodegenerative diseases, including patients with Parkinson’s disease and Alzheimer’s disease.25 Taken together, these data suggest that TDP-43 correlates with disease severity and might be relevant for further investigations for differential diagnosis.26-28. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.