This integrative approach provided deeper insights into the complex interplay of these pathways in the context of the studied condition.71 In a previous study, quantitative multiplexed proteomic analysis was employed to investigate the role of ubiquilin2 (UBQLN2) in regulating proteome composition in several Ubqln2-based murine models of ALS.72 UBQLN2, a ubiquitin receptor, binds to the proteasome through its ubiquitin-like domain, facilitating the delivery of ubiquitinated proteins for degradation. The gene discussed is UBQLN2; the disease is amyotrophic lateral sclerosis.