OPTN and amyotrophic lateral sclerosis: One of the above-mentioned studies delves into the interactomes of six ALS-associated proteins, including ATXN2, FUS, TDP-43, OPTN and UBQLN2, highlighting the common cellular pathways they regulate.84 Notably, ATXN2, FUS and TDP-43 were found to share interactors that regulate MN function through similar mechanisms, suggesting a convergence of pathogenic pathways in ALS.