Altered levels of RNA-binding motif 45 (RBM45) protein have been reported in the CSF and spinal cord of patients with ALS.68 This protein shares sequences with TDP-43 and FUS, with the ability to precipitate and form intracytoplasmic inclusions, which were found in 91% of the patients with ALS in this study. Here, RBM45 is linked to amyotrophic lateral sclerosis.