The effect of creatine supplementation on ALS progression was assessed in the SOD1-G93A mouse model and in vitro via H-NMR spectroscopy.136  In vitro, the spinal cord presented the most abnormalities, with reduced NAA and N-acetylaspartylglutamate levels and increased Glu, Tau and inositol levels. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.