Notably, a group of 189 DEPs have been recently identified in the spinal cord of SOD1-G93A mice at disease onset.70 Beyond multiple pathways identified, several of these proteins were associated with immunity and inflammation, supporting their critical role at the early disease stage of ALS.70 Xu et al. expanded upon this research by integrating proteomic and metabolomic data, offering a more comprehensive understanding of the biological processes involved. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.