This study investigated the relationship between DR and hematological parameters (PVI, MHR). Hypertension, hyperlipidemia, and chronic kidney disease were common comorbidities. NPDR patients more frequently used metformin and dipeptidyl peptidase (DPP)-4 inhibitors, while PDR patients more often used insulin (p<0.05). The gene discussed is DPP4; the disease is Hypertension.