TMPRSS2: Transmembrane protease, serine 2; IL: Interleukin; IFN-y: Interferon-y; NF-κB: Nuclear factor-kappa B; TNF-α: Tumor necrosis factor-alpha; JAK-STAT: Janus kinase-signal transducer and activator of transcription; STAT-3: Signal transducer and activator of transcription 3, PASI: Psoriasis area and severity index. The gene discussed is SOAT1; the disease is psoriasis.