SPHK2 and psoriasis: Other natural compounds, such as kaempferol found in plants, punicalagin found in pomegranates, shikonin found in roots of plants, and genistein found in soybeans, have shown potential in addressing psoriasis by targeting various immune response pathways, including JAK-STAT, CEBPD, and SPK2; however, their efficacy in providing definitive therapeutic benefits for psoriasis remains unproven [23-26].